Cadmium block of calcium current in frog sympathetic neurons
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چکیده
منابع مشابه
omega-Conotoxin block of N-type calcium channels in frog and rat sympathetic neurons.
Block of N-type Ca channels by omega-conotoxin GVIA (CgTx) was studied in freshly dissociated bullfrog and rat sympathetic neurons. With 2-5 mM Ba as charge carrier, CgTx blocked almost all of the high-threshold Ca channel current recorded in the presence of nimodipine (3 microM) to block L-type Ca channels. Toxin block reversed slowly (time constant approximately 1 hr) in frog cells and even m...
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Dihydropyridines (DHPs) generally have little effect on whole-cell calcium currents of neurons, even at concentrations far higher than those effective on muscle. Either neuronal calcium currents are much less sensitive to DHPs, or only a small proportion of the current is DHP-sensitive. We find that DHP agonists and antagonists act at low concentration on calcium currents in frog sympathetic ne...
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Cadmium block of calcium channels was studied in chicken dorsal root ganglion cells by a whole-cell patch clamp that provides high time resolution. Barium ion was the current carrier, and the channel type studied had a high threshold of activation and fast deactivation (type FD). Block of these channels by 20 microM external Cd2+ is voltage dependent. Cd2+ ions can be cleared from blocked chann...
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In many neurons, Ca(2+) signaling depends on efflux of Ca(2+) from intracellular stores into the cytoplasm via caffeine-sensitive ryanodine receptors (RyRs) of the endoplasmic reticulum. We have used high-speed confocal microscopy to image depolarization- and caffeine-evoked increases in cytoplasmic Ca(2+) levels in individual cultured frog sympathetic neurons. Although caffeine-evoked Ca(2+) w...
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I N T R O D U C T I O N C a d m i u m and many o the r inorganic cat ions t radi t ional ly cons ide red to be blockers of calcium channels may actually be pe rmean t , a lbei t spar ingly (macroscopic cur ren t data: Fakuda and Kawa, 1977; Kawa, 1979; Anderson, 1979, 1983; Brown et al., Address reprint requests to Dr. Robert H. Chow, Max-Planck-Institut f/ir Biophysikalische Chemie, Abteilung ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1992
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(92)81575-8