Cadmium block of calcium current in frog sympathetic neurons

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

omega-Conotoxin block of N-type calcium channels in frog and rat sympathetic neurons.

Block of N-type Ca channels by omega-conotoxin GVIA (CgTx) was studied in freshly dissociated bullfrog and rat sympathetic neurons. With 2-5 mM Ba as charge carrier, CgTx blocked almost all of the high-threshold Ca channel current recorded in the presence of nimodipine (3 microM) to block L-type Ca channels. Toxin block reversed slowly (time constant approximately 1 hr) in frog cells and even m...

متن کامل

Dihydropyridine actions on calcium currents of frog sympathetic neurons.

Dihydropyridines (DHPs) generally have little effect on whole-cell calcium currents of neurons, even at concentrations far higher than those effective on muscle. Either neuronal calcium currents are much less sensitive to DHPs, or only a small proportion of the current is DHP-sensitive. We find that DHP agonists and antagonists act at low concentration on calcium currents in frog sympathetic ne...

متن کامل

Calcium channel block by cadmium in chicken sensory neurons.

Cadmium block of calcium channels was studied in chicken dorsal root ganglion cells by a whole-cell patch clamp that provides high time resolution. Barium ion was the current carrier, and the channel type studied had a high threshold of activation and fast deactivation (type FD). Block of these channels by 20 microM external Cd2+ is voltage dependent. Cd2+ ions can be cleared from blocked chann...

متن کامل

Origin sites of calcium release and calcium oscillations in frog sympathetic neurons.

In many neurons, Ca(2+) signaling depends on efflux of Ca(2+) from intracellular stores into the cytoplasm via caffeine-sensitive ryanodine receptors (RyRs) of the endoplasmic reticulum. We have used high-speed confocal microscopy to image depolarization- and caffeine-evoked increases in cytoplasmic Ca(2+) levels in individual cultured frog sympathetic neurons. Although caffeine-evoked Ca(2+) w...

متن کامل

Cadmium Block of Squid Calcium Currents

I N T R O D U C T I O N C a d m i u m and many o the r inorganic cat ions t radi t ional ly cons ide red to be blockers of calcium channels may actually be pe rmean t , a lbei t spar ingly (macroscopic cur ren t data: Fakuda and Kawa, 1977; Kawa, 1979; Anderson, 1979, 1983; Brown et al., Address reprint requests to Dr. Robert H. Chow, Max-Planck-Institut f/ir Biophysikalische Chemie, Abteilung ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biophysical Journal

سال: 1992

ISSN: 0006-3495

DOI: 10.1016/s0006-3495(92)81575-8